Mn(III) porphyrins as potential MRI contrast agents for diagnosis and MRI-guided therapy

Mn(III) porphyrins have great potential as Gd-free MRI contrast agents because both the cation and ligand interesting properties. The redox properties of Mn(III)-ion can be exploited for preparation reactive oxygen species therapy. Moreover, porphyrin allows these complexes to a high affinity tumor tissues. inherent ligands make systems attractive photothermal, photodynamic, sonodynamic therapies. Therefore, are development theranostics MRI-guided For magnetic field strengths at which most clinical machines operate present (0.5–1.5 T), longitudinal relativity low-molecular-weight is even higher than that classical Gd-based agents. This review gives an overview developments in during last 30 years.